• Prävention Atemwegserkrankungen
• Grenzwerte für Stäube
• Genetische Prädisposition
• Gesundheitsrisiken durch biologische Arbeitsstoffe
• Berufliche Rehabilitation
• Evidenzbasierte Medizin
• Perinatalmedizin

Evidenzbasierte Medizin (systematische Reviews und Meta-Analysen)

Ein Schwerpunkt unserer wissenschaftlichen Tätigkeit ist die Erstellung von systematischen Reviews und Meta-Analysen sowie die Weiterentwicklung der Methodik auf diesem Gebiet. In diesem Zusammenhang interessieren uns arbeitsbezogene Endpunkte in klinischen Studien.

Ausgewählte Publikationen

• Straube S, Derry S, McQuay HJ, Moore RA. (2005) Effect of preoperative Cox-II-selective NSAIDs (coxibs) on postoperative outcomes: a systematic review of randomized studies. Acta Anaesthesiol Scand. 49: 601-13.
• Straube S, Derry S, McQuay HJ, Moore RA. (2008) Enriched enrolment: definition and effects of enrichment and dose in trials of pregabalin and gabapentin in neuropathic pain. A systematic review. Br J Clin Pharmacol. 66: 266-75.
• Straube S, Moore RA, Derry S, McQuay HJ. (2009) Vitamin D and chronic pain. Pain. 141: 10-3.
• Straube S, Tramer MR, Moore RA, Derry S, McQuay HJ. (2009) Mortality with upper gastrointestinal bleeding and perforation: effects of time and NSAID use. BMC Gastroenterol. 9: 41.
• Moore RA, Straube S, Wiffen P, Derry S, McQuay HJ. (2009) Pregabalin for acute and chronic pain in adults. Cochrane Database Syst Rev. (3): CD007076.
• Marret E, Elia N, Dahl JB, McQuay HJ, Møiniche S, Moore RA, Straube S, Tramer MR. (2009) Susceptibility to fraud in systematic reviews: lessons from the Reuben case. Anesthesiology. 111: 1279-89.
• Moore RA, Derry S, McQuay HJ, Straube S, Aldington D, Wiffen P, Bell R, Kalso E, Rowbotham MC; for the ACTINPAIN writing group of the IASP Special Interest Group (SIG) on Systematic Reviews in Pain Relief. (2010) Clinical effectiveness: an approach to clinical trial design more relevant to clinical practice, acknowledging the importance of individual differences. Pain. 149: 173-6.
• Straube S, Moore RA, Derry S, Hallier E, McQuay HJ. (2010) Vitamin D and chronic pain in immigrant and ethnic minority patients – investigation of the relationship and comparison with native Western populations. Int J Endocrinol. 2010: 753075.
• Straube S, Derry S, McQuay HJ, Moore RA. (2010) Pregabalin in fibromyalgia: meta-analysis of efficacy and safety from company clinical trial reports. Rheumatology (Oxford). 49: 706-15.
• Straube S, Derry S, McQuay HJ, Moore RA. (2010) Vitamin D for the treatment of chronic painful conditions in adults. Cochrane Database Syst Rev. (1): CD007771.
• Moore RA, Straube S, Paine J, Phillips CJ, Derry S, McQuay HJ. (2010) Fibromyalgia: Moderate and substantial pain intensity reduction predicts improvement in other outcomes and substantial quality of life gain. Pain. 149: 360-4.
• Straube S, Derry S, Moore RA, Wiffen PJ, McQuay HJ. (2010) Single dose oral gabapentin for acute postoperative pain in adults. Cochrane Database Syst Rev. (5): CD008183.
• Straube S, Derry S, Moore RA, McQuay HJ. (2010) Cervico-thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome. Cochrane Database Syst Rev. (7): CD002918.
• Moore RA, Straube S, Derry S, McQuay HJ. (2010) Chronic low back pain analgesic studies – a methodological minefield. Pain. 149: 431-4.
• Moore RA, Eccleston C, Derry S, Wiffen P, Bell RF, Straube S, McQuay H, for the ACTINPAIN writing group of the IASP Special Interest Group (SIG) on Systematic Reviews in Pain Relief and the Cochrane Pain, Palliative and Supportive Care Systematic Review Group editors. (2010) “Evidence” in chronic pain - establishing best practice in the reporting of systematic reviews. Pain. 150: 386-9.
• Straube S, Derry S, Moore RA, Paine J, McQuay HJ. (2010) Pregabalin in fibromyalgia - responder analysis from individual patient data. BMC Musculoskelet Disord. 11: 150.
• Moore RA, Straube S, Paine J, Derry S, McQuay HJ. (2011) Minimum efficacy criteria for comparisons between treatments using individual patient meta-analysis of acute pain trials – examples of etoricoxib, paracetamol, ibuprofen, and ibuprofen/paracetamol combinations after third molar extraction. Pain. 152: 982-9.
• Nicholas R, Straube S, Schmidli H, Schneider S, Friede T. (2011) Trends in annualized relapse rates in relapsing remitting multiple sclerosis and consequences for clinical trial design. Mult Scler. 17: 1211-7.
• Straube S, Moore RA, Paine J, Derry S, Phillips CJ, Hallier E, McQuay HJ. (2011) Interference with work in fibromyalgia – effect of treatment with pregabalin and relation to pain response. BMC Musculoskelet Disord. 12: 125.
• Moore RA, Straube S, Eccleston C, Derry S, Aldington D, Wiffen P, Bell RF, Hamunen K, Phillips CJ, McQuay HJ. (2012) Estimate at your peril: imputation methods for patient withdrawal can bias efficacy outcomes in chronic pain trials using responder analyses. Pain. 153: 265-8.
• Derry S, Straube S, Moore RA, Hancock H, Collins SL. (2012) Intracutaneous or subcutaneous sterile water injection compared with blinded controls for pain management in labour. Cochrane Database Syst Rev. (1): CD009107.
• Moore RA, Derry CJ, Derry S, Straube S, McQuay HJ. (2012) A conservative method of testing whether combination analgesics produce additive or synergistic effects using evidence from acute pain and migraine. Eur J Pain. 16: 585-91.
• Nicholas R, Straube S, Schmidli H, Pfeiffer S, Friede T. (2012) Time-patterns of annualized relapse rates in randomized placebo-controlled clinical trials in relapsing multiple sclerosis: A systematic review and meta-analysis. Mult Scler. 18: 1290-6.
• Rochow N, Raja P, Straube S, Voigt M. (2012) Misclassification of newborns due to systematic error in plotting birth weight percentile values. Pediatrics. 130: e347-51.
• Heesen M, Klöhr S, Hofmann T, Rossaint R, Devroe S, Straube S, Van de Velde M. (2013) Maternal and foetal effects of remifentanil for general anaesthesia in parturients undergoing caesarean section: a systematic review and meta-analysis. Acta Anaesthesiol Scand. 57: 29-36.
• Heesen M, Klöhr S, Rossaint R, Walters M, Straube S, Van de Velde M. (2013) Insertion of an intrathecal catheter after accidental dural puncture is a promising intervention for the management of headache: a meta-analysis. Int J Obstet Anesth. 22: 26-30.
• Moore RA, Straube S, Aldington D. (2013) Pain measures and cut-offs - no worse than mild pain as a simple, universal outcome. Anaesthesia. 68: 400-12.
• Seidler A, Jähnichen S, Hegewald J, Fishta A, Krug O, Rüter L, Strik C, Hallier E, Straube S. Systematic review and quantification of respiratory cancer risk for occupational exposure to hexavalent chromium. Int Arch Occup Environ Health. (Vorabveröffentlichung online)
• Heesen M, Klör S, Rossaint R, Straube S, Van de Velde M. Labour epidural analgesia and anti-infectious management of the neonate: a meta-analysis. J Perinat Med. (Vorabveröffentlichung online)
• Moore RA, Derry S, Taylor RS, Straube S, Phillips CJ. The costs and consequences of adequately managed chronic non-cancer pain and chronic neuropathic pain. Pain Pract. (Vorabveröffentlichung online)
• Steinvorth SM, Nicholas R, Röver C, Schneider S, Straube S, Friede T. Explaining temporal trends in annualized relapse rates in placebo groups of randomized controlled trials in relapsing multiple sclerosis: Systematic review and meta-regression. Mult Scler. (Vorabveröffentlichung online)